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British Journal of Anaesthesia, 1988, Vol. 61, No. 3 286-291
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

POTENCY OF ATRACURIUM AND VECURONIUM AT THE DIAPHRAGM AND THE ADDUCTOR POLLICIS MUSCLE

J. R. D. LAYCOCK, B.A., M.SC., F.F.A.R.C.S., F. DONATI, PH.D., M.D., F.R.C.P.(C.){dagger}, C. E. SMITH, B.SC., M.D., F.R.C.P.(C.) and D. R. BEVAN, M.B., M.R.C.P., F.F.A.R.C.S.

Departments of Anaesthesia, Royal Victoria Hospital and McGill University Montreal, Quebec, Canada

{dagger}Address for correspondence: Royal Victoria Hospital, Department of Anaesthesia, 687 Pine Avenue West, Montreal, Quebec, H3A 1A1 Canada.

Train-of-four stimulation was applied to the ulnar and phrenic nerves in 18 adult patients anaesthetized with nitrous oxide and halothane in oxygen. The response of the adductor pollicis and the diaphragm were measured. Incremental doses of atracurium and vecuronium were given, with an infusion to replace drug lost by elimination or distribution. The mean (SEM) doses of atracurium associated with 50% and 90% depression of response to the first stimulation in the train-of-four (ED50 and ED90) were 90 (9) and 133 (10) µg kg–1 at the adductor pollicis, and 130 (9) and 245 (17) µg kg–1 at the diaphragm, respectively. The mean (SEM) ED50 and ED90 of vecuronium were 25 (2) and 38 (4) µg kg–1 at the adductor pollicis and 34 (3) and 58 (5) µg kg–1 at the diaphragm, respectively. The mean (SEM) ED50 ratios were 1.56 (0.16) for atracurium and 1.47 (0.16) for vecuronium. ED90 ratios were 1.93 (0.29) and 1.55 (0.17) for atracurium and vecuronium, respectively. It is concluded that both atracurium and vecuronium exhibit a similar degree of sparing of the diaphragm.


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