Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by GRIFFIN, R. M.
Right arrow Articles by KAPLAN, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GRIFFIN, R. M.
Right arrow Articles by KAPLAN, J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1988, Vol. 60, No. 6 655-659
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

HAEMODYNAMIC EFFECTS OF DILTIAZEM DURING FENTANYL-NITROUS OXIDE ANAESTHESIA{dagger}

An In Vivo Study in the Dog

R. M. GRIFFIN*, I. DIMICH, R. JURADO and J. A. KAPLAN

R. M. GRIFFIN, B.M., F.F.A.R.C.S.; I. DIMICH, M.D.; R. JURADO, M.D.; J. A. KAPLAN, M.D.; Department of Anesthesiology and Division of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY 10029, U.S.A.

*Present address for correspondence: Anaesthetics Unit, The London Hospital Medical College, The London Hospital, Whitechapel, London E1 1BB.

The haemodynamic effects of diltiazem were studied in six dogs during fentanyl-nitrous oxide (in oxygen) anaesthesia. A bolus of diltiazem 300 µg kg–1 was given, followed by infusions at 30, 60 and 90 µg kg–1 min–1 which produced plasma diltiazem concentrations of 392±30, 908±54 and 1483±134 ng ml–1, respectively. Diltiazem significantly reduced systemic vascular resistance index, mean arterial pressure, heart rate and PR interval. The decrease in afterload increased cardiac index, since there was little change in myocardial contractility (LV dP/dt). Five dogs developed second degree atrioventricular (AV) block in association with the highest dose. Administration of calcium chloride 20 mg kg–1 did not reverse the haemodynamic or electrophysiological effects of diltiazem. Isoprenaline increased heart rate and restored sinus rhythm in four dogs with AV block.

{dagger}Presented in part at the 59th International Anesthesia Research Society Congress, Houston, Texas, 1985.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.