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British Journal of Anaesthesia, 1988, Vol. 60, No. 6 623-626
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARATIVE PLASMA CONCENTRATION PROFILES AFTER I.V., I.M. AND RECTAL ADMINISTRATION OF PETHIDINE IN CHILDREN

J. JACOBSEN, H. FLACHS, J. O. DICH-NIELSEN, J. ROSEN, A. B. LARSEN and E. F. HVIDBERG

JOHN JACOBSEN, M.D., JENS O. DICH-NIELSEN, M.D., JORGEN ROSEN, M.D., ANDERS B. LARSEN, M.D. (Department of Anaesthesia); HELGA FLACHS, M. PHARM. (Department of Clinical Chemistry); EIGILL F. HVIDBERG M.D., D.M.SC. (Department of Clinical Pharmacology); University of Copenhagen, Rigs-hospitalet Copenhagen, Denmark

*Address for correspondence: Department of Clinical Pharmacology, 3124, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen 0, Denmark.

Plasma concentration—time curves of pethidine and norpethidine were studied in 25 children allocated after operation to three groups to receive pethidine 1 mg kg–1 i.v., i.m. or rectally. Peak concentrations occurred after 5± 1, 10 ± 2, and 60 ± 10 min, respectively, while the maximum concentrations amounted to 2800±462, 1609 ± 367 and 531 ±179 nmol litre–1, respectively. The area under the curve (0–240 min) was similarly reduced in the group with rectal administration (P < 0.05). Compared with the i.v. data, approximately 40% systemic availability occurred after rectal application, although considerable individual variastion was noted. In one child very high plasma concentrations were observed after rectal administration, possibly as a result of redistribution/recirculation phenomena. The average results are similar to those obtained when other opioids are given rectally.


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