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British Journal of Anaesthesia, 1988, Vol. 60, No. 5 579-581
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF NIFEDIPINE ON CARDIOVASCULAR RESPONSES TO LARYNGOSCOPY AND INTUBATION

G. D. PURI, M.D. and Y. K. BATRA, M.D.

Department of Anaesthesia, Postgraduate Institute of Medical Education and Research Chandigarh-160 012, India

Correspondence to G.D.P.

The efficacy of sublingual nifedipine in attenuating the pressor responses to laryngoscopy and intubation was studied in 40 patients undergoing elective surgery. Anaesthesia was induced with thiopentone 5.5 mg kg–1 i.v. and tracheal intubation was facilitated with suxamethonium 1.5 mg kg–1 i.v. Patients were allocated randomly to receive sublingual nifedipine 10 mg or placebo capsules 10 min before induction. Patients receiving placebo capsule showed significant increases in heart rate and arterial pressure associated with tracheal intubation (P<0.001). The increases in arterial pressure and rate-pressure product were reduced in nifedipine treated patients (P<0.001). Heart rate increased significantly in both groups immediately after intubation.


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