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British Journal of Anaesthesia, 1988, Vol. 60, No. 5 536-541
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ADRENOCORTICAL HORMONE CONCENTRATIONS IN CHILDREN DURING CARDIOPULMONARY BYPASS WITH AND WITHOUT PULSATILE FLOW

E. M. M. POLLOCK, F.F.A.R.C.S., J. C. S. POLLOCK, F.R.C.S., M. P. G. JAMIESON, F.R.C.S., G. S. BEASTALL, PH.D., C. WRIGHT, B.SC., B. TORSNEY, PH.D. and L. R. McNICOL, F.F.A.R.C.S.

Department of Anaesthesia, Royal Hospital for Scik Children Yokhill, Glasgow G3 8SJ
Department of Cardiac Surgery, Royal Hospital for Scik Children Glasgow
Glasgow Royal Infirmary Glasgow
Department of Statistics, Glasgow University Glasgow
Present address: Department of Anaesthesia, Toronto Children's Hospital Toronto, Ontario, Canada

Correspondence to L.R.McN.

Plasma cortisol and ACTH concentrations were measured in two groups of children (aged 1–16 yr). Ten children underwent routine (non-pulsatile) cardiopulmonary bypass and 10 underwent pulsatile bypass under moderate hypothermia (28–32°C). Comparable increases in cortisol and ACTH concentrations were demonstrated at the onset of bypass and the concentrations of both hormones increased during bypass. In the post-bypass period plasma cortisol concentration increased sharply; there was no further increase in the plasma ACTH concentration. By 24 h the concentrations of both hormones had declined towards baseline values. There were no significant differences between the groups.


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