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British Journal of Anaesthesia, 1988, Vol. 60, No. 5 530-535
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF SUFENTANIL-OXYGEN AND FENTANYL-OXYGEN ANAESTHESIA FOR CORONARY ARTERY BYPASS GRAFTING

H. M. L. MATHEWS, M.B., F.F.A.R.C.S., G. FURNESS, M.B., F.F.A.R.C.S., I. W. CARSON, M.D., F.F.A.R.C.S., I. A. ORR, M.D., F.F.A.R.C.S., S. M. LYONS, M.D., F.F.A.R.C.S. and R. S. J. CLARKE, M.D., PH.D., F.F.A.R.C.S.

Department of Anaesthetics, The Queen's University of Belfast Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL
Department of Clinical Anaesthesia and Cardiac Surgical Unit, Royal Victoria Hospital Belfast

Correspondence to R.S.J.C.

Haemodynamic variables were compared in 40 adults undergoing coronary artery bypass grafting during anaesthesia induced with either sufentanil 5 µg kg–1 or fentanyl 25 µg kg–1 in combination with pancuronium 0.1 mg kg–1. Further doses of sufentanil 2.5 µg kg–1 or fentanyl 12.5 fig kg–1 were given before skin incision and again before sternotomy. All patients were receiving ß-adrenoceptor blocking therapy. Satisfactory induction of anaesthesia was produced with both drugs and opioid supplementation prevented any marked haemodynamic response to skin incision and to sternotomy. Following induction of anaesthesia, sufentanil produced the greater decrease in mean arterial pressure and left ventricular stroke work index which continued throughout the study. This suggests that, in the doses used in this study, sufentanil is preferable to fentanyl in patients with coronary artery disease.


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