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British Journal of Anaesthesia, 1988, Vol. 60, No. 5 495-499
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DIFFERENTIAL EFFECTS OF CALCIUM CHANNEL BLOCKING AGENTS ON PANCURONIUM- AND SUXAMETHONIUM-INDUCED NEUROMUSCULAR BLOCKADE

A. SALVADOR, B.S., E. DEL POZO, M.D., R. CARLOS, M.D. and J. M. BAEYENS, M.D.

Department of Pharmacology and Anaesthesia, University of Granada Medical School 18012 Granada, Spain

Correspondence to J. M. B.

The effects were studied of several calcium channel blocking agents on muscle twitch, and possible interactions between these drugs and pancuronium and suxamethonium, using a rat phrenic-hemidiaphragm preparation. Nicardipine, verapamil and diltiazem each caused a concentration-related depression of muscle response. Nicardipine had the most, and diltiazem the least, potent effect. Verapamil and diltiazem 5 and 10µmol litre–1 caused a concentration-dependent enhancement of suxamethonium-induced neuromuscular blockade, but increased the effect of pancuronium only at 10 µmol litre–1. Nicardipine 10µmol litre–1 significantly enhanced pancuronium-induced neuromuscular blockade, but not that produced by suxamethonium.


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