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British Journal of Anaesthesia, 1988, Vol. 60, No. 5 491-494
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

MAINTENANCE OF CONSTANT 95% NEUROMUSCULAR BLOCKADE BY ADJUSTABLE INFUSION RATES OF PANCURONIUM AND ATRACURIUM

V. Y. HARALDSTED, M.D.*, J. W. NIELSEN, M.D., J. V. MADSEN, M.D. and L. HASSELSTRØM, M.D.

Department of Anaesthesia and Intensive Care, Randers Centralsygehus DK 8900 Randers, Denmark

*Address for correspondence: Schleppegrellsgade 7,1, DK8000 Århus C, Denmark

In a double-blind study, 39 patients (ASA groups I-II) were given either pancuronium or atracurium as an infusion during surgery. The drugs were given as an initial loading dose of 0.064 mg kg–1 or 0.30 mg kg–1, respectively, followed by an infusion, the rate of which was regulated to produce a constant 95% depression of the evoked twitch response throughout surgery. No significant difference in the number of corrections of the infusion rate per hour was found (4.6 v. 4.9). Mean infusion maintenance doses were 35 and 356 µg kg–1 h–1 respectively. The inter-individual variability of maintenance doses for the two drugs did not differ, the coefficients of variation being 0.32 and 0.24. On stopping the infusion, the patients given atracurium recovered to a 15% twitch faster than those given pancuronium. In addition neostig-mine produced a quicker recovery in this group. Thus atracurium may be a more satisfactory drug for use by infusion.


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