Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by KARLIN, A.
Right arrow Articles by COTTRELL, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KARLIN, A.
Right arrow Articles by COTTRELL, J. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1988, Vol. 60, No. 2 161-166
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

RATE OF INDUCTION OF HYPOTENSION WITH TRIMETAPHAN MODIFIES THE INTRACRANIAL PRESSURE RESPONSE IN CATS

A. KARLIN, M.D., J. HARTUNG, PH.D. and J. E. COTTRELL, M.D.

Department of Anesthesiology, State University of New York Health Science Center at Brooklyn 450 Clarkson Avenue, Box 6, Brooklyn, New York 11203.

Correspondence to A.K.

An infusion of 0.1% trimetaphan was administered to eight cats with artificially increased intracranial pressure (ICP) in order to decrease their mean arterial pressure (MAP) from 121±9.5 (SEM) to 58±4.6 mm Hg in less than 1 min. All cats developed an increase in intracranial pressure (ICP) (from 16±1.4 to 23±3.2 mm Hg) accompanied by a partial rebound in MAP. Eight additional cats received 0.1%trimetaphan to decrease their MAP from 128±13.4 to 52±8.1 mm Hg over more than 2 min. Four of these cats followed the same pattern, with ICP increases from 19 ±1.1 to 31±3.9 mm Hg, while in the other four ICP did not change. In nine of the 12 cats with an ICP increase, that increase was initiated before the partial MAP rebound. We conclude that trimetaphan causes clinically significant ICP increases in cats with increased ICP, that partial rebound in MAP frequently exacerbates these increases in ICP, and that rapid induction of hypotension tends to increase the frequency with which trimetaphan increases ICP.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.