British Journal of Anaesthesia, 1988, Vol. 60, No. 2 146-150
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia
research-article |
PHARMACOKINETICS OF PROPOFOL (DIPRIVAN) IN ELDERLY PATIENTS
Department of Anaesthesia, University of Sheffield Medical School Beech Hill Road, Sheffield S10 2RX.
Pharmacokinetics Section, Safety of Medicines Department, ICI Pharmaceuticals Division Macclesfield, Cheshire SK10 4TG.
The pharmacokinetics of propofol (2,6 diisopropylphenol) were compared in 12 patients aged 65–80 yr and 12 patients aged 18–35 yr. After premedication with papaveretum i.m., anaesthesia was induced with propofol 2.0 mg kg–1 in the elderly and 2.5 mg kg–1 in the younger patients. Alcuronium 12–20 mg was then given and the patient's lungs ventilated with halothane and nitrous oxide in oxygen. Blood was taken after various time intervals up to 24 h for the measurement of propofol concentrations by HPLC and for the estimation of propofol protein binding. The mean blood propofol concentration was generally higher in the elderly group, but this difference was only significant at 2 min after induction. The clearance of propofol was significantly lower in the elderly (1.44±0.10 (SE) litre min–1) than in the younger patients (1.79±0.12 litre min–1). The volume of the central compartment in the elderly patients was significantly smaller (19.6±5.2 litre) than that in the young (26.3±2.9 litre). There was no difference in the volume of distribution at equilibrium (1608±246 litre in the elderly and 1757±360 litre in the young), in the volume of distribution at steady state (691±139 litre in the elderly and 771±236 litre in the young) or in the half-lives of distribution and elimination. The plasma protein binding of propofol was similar in both groups and showed no trend with time after dose.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Hama-Tomioka, H. Kinoshita, T. Azma, K. Nakahata, N. Matsuda, N. Hatakeyama, H. Kikuchi, and Y. Hatano The Role of 20-Hydroxyeicosatetraenoic Acid in Cerebral Arteriolar Constriction and the Inhibitory Effect of Propofol Anesth. Analg., December 1, 2009; 109(6): 1935 - 1942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. S. Gragasin and S. T. Davidge The effects of propofol on vascular function in mesenteric arteries of the aging rat Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H466 - H474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Glen and F. Servin Evaluation of the predictive performance of four pharmacokinetic models for propofol Br. J. Anaesth., May 1, 2009; 102(5): 626 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kinoshita, N. Matsuda, Y. Kimoto, S. Tohyama, K. Hama, K. Nakahata, and Y. Hatano Sevoflurane, but Not Propofol, Prevents Rho Kinase-Dependent Contraction Induced by Sphingosylphosphorylcholine in the Porcine Coronary Artery Anesth. Analg., August 1, 2007; 105(2): 325 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. O. Nafiu Is a Desflurane-Remifentanil Based Anesthetic Really the Best for the Wake-Up Test? Anesth. Analg., July 1, 2005; 101(1): 296 - 296. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Abad-Santos, M. A. Galvez-Mugica, M. A. Santos, J. Novalbos, S. Gallego-Sandin, P. Mendez, C. Casimiro, and F. Gilsanz Pharmacokinetics and Pharmacodynamics of a Single Bolus of Propofol 2% in Healthy Volunteers J. Clin. Pharmacol., April 1, 2003; 43(4): 397 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Favetta, C.-S. Degoute, J.-P. Perdrix, C. Dufresne, R. Boulieu, and J. Guitton Propofol metabolites in man following propofol induction and maintenance Br. J. Anaesth., May 1, 2002; 88(5): 653 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. He, H. Seno, K. Sasaki, and C. Tashiro The Influences of Maternal Albumin Concentrations on the Placental Transfer of Propofol in Human Dually Perfused Cotyledon In Vitro Anesth. Analg., May 1, 2002; 94(5): 1312 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Severn Editorial II: Time to light the grey touchpaper! The challenge of anaesthesia in the elderly Br. J. Anaesth., October 1, 2001; 87(4): 533 - 536. [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Priebe The aged cardiovascular risk patient Br. J. Anaesth., November 1, 2000; 85(5): 763 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. He, S. Tsujimoto, M. Tanimoto, R. Okutani, K. Murakawa, and C. Tashiro Effects of protein binding on the placental transfer of propofol in the human dually perfused cotyledon in vitro Br. J. Anaesth., August 1, 2000; 85(2): 281 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fujita, J. Higuchi, T. Nagai, S. Tokudome, and H. Sakio A Simple Method for Detecting Plasma Propofol Anesth. Analg., June 1, 2000; 90(6): 1452 - 1454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Olmos, J. A. Ballester, M. A. Vidarte, J. L. Elizalde, and A. Escobar The Combined Effect of Age and Premedication on the Propofol Requirements for Induction by Target-Controlled Infusion Anesth. Analg., May 1, 2000; 90(5): 1157 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhou, H. J. Fontenot, S.-N. Wang, and R. H. Kennedy Propofol-Induced Alterations in Myocardial {beta}-Adrenoceptor Binding and Responsiveness Anesth. Analg., September 1, 1999; 89(3): 604 - 604. [Abstract] [Full Text] [PDF]
|
|