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British Journal of Anaesthesia, 1988, Vol. 60, No. 2 136-139
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PLASMA PRILOCAINE CONCENTRATIONS AFTER THREE TECHNIQUES OF BRACHIAL PLEXUS BLOCKADE

D. MACLEAN, M.R.C.P., F.F.A.R.C.S., W. A. CHAMBERS, M.D., F.F.A.R.C.S., G. T. TUCKER, B.PHARM., PH.D. and J. A. W. WILDSMITH, M.D., F.F.A.R.C.S.

Department of Anaesthetics, Royal Infirmary of Edinburgh Edinburgh, EH3 9YW.
Department of Therapeutics, Hallamshire Hospital Sheffield

Brachial plexus blockade (n = 30: 10 axillary, 10 perivascular subclavian, 10 interscalene) was performed on 28 patients, using 35 ml of 1.5% prilocaine in plain solution. Plasma prilocaine concentrations were measured at intervals over the following 60 min. There was no significant difference in the prilocaine concentrations between the three groups. One asymptomatic patient in the interscalene group had a peak prilocaine concentration greater than the accepted threshold for toxic symptoms.


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