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British Journal of Anaesthesia, 1988, Vol. 60, No. 2 130-135
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PLASMA GLUTATHIONE S-TRANSFERASE CONCENTRATION AS A MEASURE OF HEPATOCELLULAR INTEGRITY FOLLOWING A SINGLE GENERAL ANAESTHETIC WITH HALOTHANE, ENFLURANE OR ISOFLURANE

A. J. HUSSEY, M. PHIL., L. M. ALDRIDGE, F.F.A.R.C.S., D. PAUL, F.F.A.R.C.C.S., D. C. RAY, M.B., CH.B., G. J. BECKETT, PH. D. and L. G. ALLAN, F.F.A.R.C.S.*,

University Department of Clinical Chemistry, The Royal Infirmary Edinburgh EH3 9YW
University Departmnet of Anaesthetics, The Royal Infirmary Edinburgh EH3 9YW

*Present address: Northwick Park Hospital and Clinical Research Centre, Watford Road, Harrow, Middlesex.

Correspondence to L.M.A

The plasma concentration of hepatic glutathione S-transferase (GST) was measured in matched groups of patients who received halothane, enflurane or isoflurane anaesthesia for elective minor surgery. The GST concentrations increased significantly at 3 h after anaesthesia in patients who received halothane or enflurane, but not in patients who were given isoflurane. A secondary increase in GST concentration, at 24 h, was seen in a small number of individuals who received halothane or enflurane. Abnormal GST concentrations were found in 50% of patients following halothane anaesthesia, 20% following enflurane and 11% after isoflurane. The small but significant increases in GST concentrations in patients receiving halthane or enflurane suggests an impairment of hepatocellular integrity following the administration of these anaesthetics. In contrast, isoflurane anaesthesia did not apear to be associated with this effect.


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