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British Journal of Anaesthesia, 1988, Vol. 60, No. 1 91-97
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PULMONARY TOXICITY AFTER TREATMENT WITH BLEOMYCIN ALONE OR IN COMBINATION WITH HYPEROXIA

Studies in the Rat

M. C. BLOM-MUILWIJK, R. VRIESENDORP{dagger}, T. S. VENINGA, W. HOFSTRA, D. T. SLEYFER, R. A. WIERINGA and A. W. T. KONINGS

Academic Medical Centre Meiberg-dreef 9, 1105 AZ Amsterdam, The Netherlands.
Department of Medical Oncology, University Hospital Groningen Oostersingel 59, 9713 EZ Groningen, The Netherlands.
Department of Radiopathology, University of Groningen Bloemsingel 1, 9713 BZ Groningen, The Netherlands.
Central Animal Laboratory, State University of Groningen Ant. Deusinglaan 50, 9713 AZ Groningen, The Netherlands.

Correspondence to T.S.V.

Female Wistar rats (n = 11) received bleomycin 10 mg kg–1 i.p. three times weekly for 6 weeks. Four weeks later part of the group (n = 7) were exposed to 50% oxygen in air for 4 h; the others served as unexposed controls. A further control group (n = 5) received physiological saline i.p. and was not exposed to oxygen. One week after the hyperoxia treatment all animals were sacrificed and the lungs prepared for histological and biochemical determinations. Although the average body weight of the bleomycin-treated rats decreased significantly compared with the saline-treated controls, no significant alterations in lung histology were found in regard to the occurrence of oedema, fibrosis, and type II pneumocytes. Intra-alveolar macrophages were significantly increased. Subsequent hyperoxia did not lead to a more pronounced effect, except for macrophage accumulation. The activities of superoxide dismutase and glutathione per-oxidase were not changed either after administration of bleomycin alone or after combination with hyperoxia. It is concluded that bleomycin i.p. in doses comparable to those encountered clinically, administered alone or combined with hyperoxia, does not result in pulmonary damage in female Wistar rats.

{dagger}Present address: Westeinde Hospital, Department of Medical Oncology, PO Box 432, 2501 CK Den Haag, The Netherlands.


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