Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (27)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MAUNUKSELA, E.-L.
Right arrow Articles by OLKKOLA, K. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MAUNUKSELA, E.-L.
Right arrow Articles by OLKKOLA, K. T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1988, Vol. 60, No. 1 48-55
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DOUBLE-BLIND, MULTIPLE-DOSE COMPARISON OF BUPRENORPHINE AND MORPHINE IN POSTOPERATIVE PAIN OF CHILDREN

E.-L. MAUNUKSELA, M.D., R. KORPELA, M.D. and K. T. OLKKOLA, M.D.

Children's Hospital, University of Helsinki Stenbäckinkatu 11, SF-00290 Helsinki, Finland.
Department of Clinical Pharmacology, University of Helsinki Paasikivenkatu 4, SF-00250 Helsinki, Finland.

In a randomized double-blind study of 57 children (aged 6 months–6 yr), pain following lateral thoracotomy was relieved with repeated i.v. doses of morphine 100 or 50 µg kg–1, or buprenorphine 3.0 or 1.5 µg kg–1. The same drug and dosage were continued and cardio-ventilatory indices, pain intensity and sedation measured for an observation period of 24 h. The sums of the pain intensity differences were equal in all groups. The mean doses for the complete initial analgesia were 230 and 180 µg kg–1 with the larger and the smaller bolus doses of morphine and 5.8 and 3.7 µg kg–1 with buprenorphine, respectively. The mean duration of action of buprenorphine was slightly but not significantly longer than that of morphine. The total consumption of both morphine and buprenorphine was less when the smaller bolus doses were used. Two patients developed a degree of ventilatory depression following repeated doses of buprenorphine. Buprenorphine was equal to morphine as a postoperative analgesics.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Journal of Pharmacy PracticeHome page
P. C. Walker and D. S. Wagner
Treatment of Pain in Pediatric Patients
Journal of Pharmacy Practice, August 1, 2003; 16(4): 261 - 275.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.