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British Journal of Anaesthesia, 1987, Vol. 59, No. 6 735-737
© 1987 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECTS OF H-2 ANTAGONISTS ON THE ELIMINATION OF BUPIVACAINE

D. W. NOBLE, B.MED.BIOL., F.F.A.R.C.S.*,, K. J. SMITH, PH.D. and C. R. DUNDAS, F.F.A.R.C.S., F.R.C.P. (GLAS.)

Department of Anaesthesia, Aberdeen Royal Infirmary Foresterhill, Aberdeen
Department of Therapeutics and Clinical Pharmacology, University of Aberdeen Foresterhill, Aberdeen

*Present address: Department of Anaesthetics, Royal Infirmary, Edinburgh EH3 9YW.

The effects of two histamine H-2 antagonists, cimetidine and ranitidine, on the elimination of bupivacaine were studied in four male volunteers. The cimetidine-treated group demonstrated a statistically significant decrease in clearance of bupivacaine. These results indicate that concomitant administration of cimetidine and bupivacaine may increase the likelihood of toxicity of the latter agent.


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