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British Journal of Anaesthesia, 1987, Vol. 59, No. 6 730-734
© 1987 The Board of Management and Trustees of the British Journal of Anaesthesia

other

CALCIUM AND MAGNESIUM CONTENT OF SKELETAL MUSCLE

Studies in Subjects Undergoing Diagnostic Testing for Malignant Hyperthermia

T. E. NELSON, PH.D.,§, E. H. FLEWELLEN, M.D.,, M. W. BELT, M.D., D. L. KENNAMER, M.D., O. E. WINSETT, M.D.{dagger} and D. E. BEE, PH.D.{ddagger}

Departments of Anesthesiology The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.
§Departments of Pharmacology and Toxicology The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.
{dagger}Departments of Surgery The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.
{ddagger}Departments of Preventive Medicine community Health The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.
Department of Anesthesiology Scott & White Clinic, Temple, Texas 76508, U.S.A.

Ca2+ and Mg2+ contents were measured and compared among three different malignant hyperthermia susceptible (MHS) diagnostic groups. No difference was found among mean values for Ca2+ content, whereas Mg2+ content was greater in MHS muscle. Variance of measured values was unequal and greatest among MHS muscles, suggesting a possible abnormal distribution associated with MHS. Although more muscle fibres with Ca2+ ≤ 12 µmol g–1 were observed in MHS muscle, this difference was not statistically significant. In contrast, non-parametric analysis showed that the population of Mg2+ values was significantly greater in the MHS muscle. This study suggests that the distribution of Ca2+ and Mg2+ values is different in MHS muscle as a result of unknown genetic factors associated with the disease.


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 Br J AnaesthHome page
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Mg2+ dependence of Ca2+ release from the sarcoplasmic reticulum induced by sevoflurane or halothane in skeletal muscle from humans susceptible to malignant hyperthermia
Br. J. Anaesth., September 1, 2006; 97(3): 320 - 328.
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