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British Journal of Anaesthesia, 1987, Vol. 59, No. 6 721-724
© 1987 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECT OF I.V. LIGNOCAINE ON PAIN AND THE ENDOCRINE METABOLIC RESPONSES AFTER SURGERY

K. BIRCH, M.D., J. JØRGENSEN, M.D., B. CHRÆMMER-JØRGENSEN, M.D. and H. KEHLET, M.D.

Department of Gynecology and Obstetrics;Glostrup Hospital DK-2600 Glostrup, Denmark
Department of Anaesthesiology; Glostrup Hospital DK-2600 Glostrup, Denmark
Department of Surgical Gastroenterology, Hvidovre Hospital Hvidovre, Denmark

Correspondence to K.B.

Pain intensity, and blood glucose and plasma cortisol concentrations were measured following abdominal hysterectomy in 18 patients allocated randomly to receive either i.v. lignocaine 1.5 mg kg–1 plus 2 mg kg–1 h–1, or saline. The administration of lignocaine resulted in plasma conentrations between 1.5 and 2.0 µg ml–1 during the 2-h study period. However, the administration of lignocaine i.v. had no effect on the intensity of pain after surgery, or on the adrenocortical and hyperglycaemic responses to surgery.


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