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British Journal of Anaesthesia, 1987, Vol. 59, No. 6 713-720
© 1987 The Board of Management and Trustees of the British Journal of Anaesthesia

other

FENTANYL AND THE ß-ENDORPHIN, ACTH AND GLUCOREGULATORY HORMONAL RESPONSE TO SURGERY

S. LACOUMENTA, M.D., F.F.A.R.C.S.I.,, J. L. PATERSON, B.SC.,, G. M. HALL, M.B.B.S., PH.D., C.BIOL., M.I. BIOL., F.F.A.R.C.S, T. H. YEO, B.SC., PH.D.,, J. M. BURRIN, B.SC., PH.D., and S. R. BLOOM, M.A., M.D., D.SC., F.R.C.P.

Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital Ducane Road, London W12 OHS.
Department of Medicine; Royal Postgraduate Medical School, Hammersmith Hospital Ducane Road, London W12 OHS.

Correpondence to G.M.H.

The effect of the supplementation of nitrous oxide—oxygen anaesthesia with either fentanyl 15 µg kg–1 or 0.5% halothane on the ß-endorphin, ACTH, glucoregulatory hormonal and metabolic response to pelvic surgery was investigated. Fentanyl inhibited the increases in circulating ß-endorphin, ACTH, growth hormone, cortisol and glucose concentrations found in the patients receiving halothane. Changes in circulating ß-endorphin concentrations during surgery probably reflect alterations in pituitary secretion and appear to have no major metabolic effects. The suppression of pituitary secretion persisted for at least 4 h after the start of surgery.


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