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British Journal of Anaesthesia, 1987, Vol. 59, No. 6 707-712
© 1987 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECTS OF ALFENTANIL ON THE PRESSOR AND CATECHOLAMINE RESPONSES TO TRACHEAL INTUBATION

D. C. CRAWFORD, M.B., M.R.C.P., F.F.A.R.C.S.*, D. FELL, M.B., F.F.A.R.C.S., K. J. ACHOLA, B.SC., M.SC. and G. SMITH, M.D., F.F.A.R.C.S.

University Department of Anaesthesia, Leicester Royal Infirmary, Leicester LE1 5WW.

*Present address: Department of Anaesthesia, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP.

Correspondence to D. F.

The effects of alfentanil (given during induction of anaesthesia) on the haemodynamic and catecholamine responses to tracheal intubation were studied in 44 adult patients who received alfentanil 10 µg kg–1 or 40 µg kg–1, or saline placebo. Alfentanil 10 µg kg–1 and 40 fig kg–1 prevented any increase in heart rate and arterial pressure after tracheal intubation. Alfentanil 40 µg kg–1 produced profound hypotension and bradycardia. The use of alfentanil in both doses was associated with a decrease in plasma adrenaline concentrations after tracheal intubation.


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