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British Journal of Anaesthesia, 1987, Vol. 59, No. 6 697-706
© 1987 The Board of Management and Trustees of the British Journal of Anaesthesia

other

PHARMACOKINETICS OF ATRACURIUM AND ITS METABOLITES IN PATIENTS WITH NORMAL RENAL FUNCTION, AND IN PATIENTS IN RENAL FAILURE

S. WARD, F.F.A.R.C.S.*, N. BOHEIMER, F.F.A.R.C.S., B. C. WEATHERLEY, PH.D., R. J. SIMMONDS, PH.D.{dagger} and T. A. DOPSON

Anaesthetic Department Kings College Hospital, London
Department of Drug Metabolism, The Wellcome Research Laboratories Beckenham, Kent, BR3 3BS

Correspondence to B.C.W.

The plasma pharmacokinetic profiles of atracurium and its derivatives, lafdanosine and monoquaternary alcohol, were studied in six patients with renal failure after a bolus dose of atracurium 0.3–0.4 mg kg–1. The pharmacokinetics of the derivatives only were studied in a group of four normal patients receiving atracurium 0.3 mg kg–1. Measurements of plasma and urine concentrations were performed by high pressure liquid chromatography. Pharmacokinetics of atracurium were not significantly different in the renal failure group when compared with those obtained in a previous study on six normal patients. Although 2–10% of the dose was recovered in the urine of normal patients as unchanged atracurium, and 3–4% as lafdanosine, renal failure produced no significant differences in plasma pharmacokinetics, with mean plasma elimination half-lives of 20 min for atracurium, 234 min for lafdanosine and 39 min for quaternary alcohol.

*Southend Hospital, Prittlewell Chase, Westcliff-on-Sea, Essex SSO ORY.

{dagger}Upjohn Limited, Fleming Way, Crawley, West Sussex RH10 2NJ.


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