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British Journal of Anaesthesia, 1986, Vol. 58, No. suppl_1 83S-88S
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

Circulatory Effects of Atracurium in Patients with Cardiovascular Disease

J. R. Moyers, M.D., J. G. Carter, M.D., B. L. Fehr, M.P.H., C. C. Lineberry, PH.D., M. D. Sokoll, M.D. and S. Shimosato, M.D., PH.D.

Department of Anesthesia, University of Iowa Iowa City, Iowa 52242, U.S.A.
Anesthesiology Section, Burroughs Wellcome Co. 3030, Cornwallis Road, Research Triangle Park, NC 27709, U.S.A.

Abstract

Atracurium 0.4 mg kg–1 which was sufficient to produce neuromuscular blockade sufficient for intubation, was administered as divided bolus doses to 40 patients with severe cardiovascular disease. Little haemodynamic change occurred. A transient reduction in arterial pressure was noted in one patient. Atracurium was found to be safe and effective, and administration in small bolus doses separated by 30 may reduce the likelihood of significant circulatory changes.


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