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British Journal of Anaesthesia, 1986, Vol. 58, No. suppl_1 6S-10S
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

Pharmacokinetics of Atracurium and its Metabolites

S. Ward, F.F.A.R.C.S. and B. C. Weatherley, PH.D.

Anaesthetic Department, Southend General Hospital Prittlewell Chase, Westcliffe-on-Sea, Essex SS0 ORY
Wellcome Research Laboratories Langley Court, Beckenham, Kent

Abstract

The pharmacokinetic profile of atracurium was studied in normal patients and in patients with renal failure, renal-hepatic failure, or hepatic disease. Its short elimination half-life was not significantly altered by renal failure, but in patients with severe liver disease elimination of its metabolites was prolonged, necessitating care during long-term i.v. infusions in patients with hepatic dysfunction.


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