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British Journal of Anaesthesia, 1986, Vol. 58, No. suppl_1 60S-62S
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

Atracurium Administered by Infusion for Long Neurosurgical Procedures

J. Vestergaard Madsen, M.D., B. Normark Andersen, M.D., B. Asmin Schurizek, M.D., O. Viborg Jensen, M.D. and B. Juhl, M.D.

Department of Anaesthesia, University Hospital of Aarhus, Aarhus Kommunehospital DK-8000 Aarhus C, Denmark

Abstract

In a clinical trial of atracurium given by continuous infusion at 0.5 mg kg–1 h–1 during craniotomy in 15 patients anaesthetized with thiopentone, pentobarbitone, fentanyl and nitrous oxide in oxygen, neuromuscular blockade was evaluated using train-of-four (TOF) and twitch height (TH). A bolus of atracurium was given initially and an infusion of atracurium 0.5 mg kg–1 h–1 was started when TH 0.05 reappeared. The median duration of infusion was 190 min (range 42–285 min) and the median total dose was 2.2 mg kg-1 (range 0.9–3.1 mg kg–1). Spontaneous recovery from neuromuscular blockade (TOF = 0.70) occurred 44 min (range 30–95 min) following termination of infusion. The recovery time from neuromuscular blockade was independent of duration of infusion within 5 h.


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