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British Journal of Anaesthesia, 1986, Vol. 58, No. suppl_1 44S-48S
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

Atracurium in Patients with Renal Failure

Clinical Trial of a New Neuromuscular Blocker

D. Mongin-Long, M.D., B. Chabrol, M.D., C. Baude, M.D., D. Ville, M.D., M. Renaudie, M.D., J. M. Dubernard, M.D. and J. F. Moskovtchenko, M.D.

Edouard Herriot Hospital 69374 Lyon
Vth Department of Anaesthesia Edouard Herriot Hospital 69374 Lyon
Department of Urology and Transplant Surgery Edouard Herriot Hospital 69374 Lyon
Department of Nuclear Medicine Edouard Herriot Hospital 69374 Lyon
Wellcome Laboratory 159 rue Nationale, 75013, Paris, France

Correspondence to D. M.-L., Vth Department of Anaesthesia, Edouard Herriot Hospital, 69374, Lyon, France.

Abstract

Atracurium was given to 30 patients with terminal chronic renal insufficiency, in two regimens. Group I (20 patients) received a single dose of 0.6 mg kg–1 and group II (10 patients), received one or several injections of 0.2 mg kg–1. Tracheal intubation was performed with ease in all patients 3 min after the injection of atracurium. A supramaximal stimulus was applied to the ulnar nerve at wrist level, and thumb adduction force was recorded. Muscular blockade was 100% in 29/30 patients and 95% in one. Mean time between atracurium injection and reappearance of 25% of the initial muscular power (HT25) was 49 min. The recovery time index (IR25–75) was 12 min and did not increase after re-injection. No side-effects were observed and no significant differences in any of the measurements made were seen between the two groups.


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