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British Journal of Anaesthesia, 1986, Vol. 58, No. 4 451-456
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

REVERSAL OF NITROUS OXIDE-INDUCED DEPRESSION OF HYPOXIC PULMONARY VASOCONSTRICTION BY LIGNOCAINE HYDROCHLORIDE DURING COLLAPSE AND VENTILATION HYPOXIA OF THE LEFT LOWER LOBE

L. BINDSLEV, M.D.*, D. CANNON, B.SC. and M. K. SYKES, M.A., M.B., B. CHIR., F.F.A.R.C.S., F.F.A.R.A.C.S.

Nuflield Department of Anaesthetics Radcliffe Infirmary, Oxford

*Department of Anesthesia, Karolinska Hospitalm, 1041 Stockholm, Sweden.

The blood flow to the left lower lobe (FormulaL), and total (FormulaT) pulmonary blood flow, were measured in 10 open-chest dogs using electromagnetic flowmeters. Ventilation of the left lower lobe with 7% oxygen in nitrogen produced a greater reduction in FormulaL/FormulaT (41%) than lobar ventilation with 7% oxygen in nitrous oxide (33%). Lobar collapse reduced QL/QT by 65%, but there was no change in FormulaL/FormulaT when 50% nitrous oxide was administered to the right lung. The i.v. infusion of lignocaine hydrochloride during ventilation of the lobe with 7% oxygen in nitrogen produced no change in FormulaL/FormulaT. However, lignocaine infusion during lobar ventilation with 7% oxygen in nitrous oxide produced a further reduction in FormulaL/FormulaT to a value which was not significantly different from that observed during ventilation with 7% oxygen in nitrogen. Lignocaine had no effect on FormulaL/FormulaT during lobar collapse whether the right lung was ventilated with 50% oxygen in nitrogen or 50% oxygen in nitrous oxide. It is concluded that lignocaine reverses the depression of hypoxic pulmonary vasoconstriction produced by lobar ventilation with nitrous oxide.


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