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British Journal of Anaesthesia, 1986, Vol. 58, No. 4 441-443
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECT OF VECURONIUM ON INTRACRANIAL PRESSURE, MEAN ARTERIAL PRESSURE AND HEART RATE IN CATS

J. P. GIFFIN, M.D.*, J. HARTUNG, PH.D., J. E. COTTRELL, M.D., C. CAPUANO, B.S. and B. SHWIRY, C.R.N.A.

Departments of Anesthesiology, Kings Country Hospital Center and State University Hospital, Downstate Medical Center 450 Clarkson Avenue, Brooklyn, New York, 11203.

*Department of Anesthesiology, Kings County Hospital Center, 451 Clarkson Avenue, Brooklyn, New York 11203, U.S.A.

The effect of vecuronium on intracranial pressure (ICP) was investigated in six cats with normal and increased ICP. Cats were anaesthetized with pentobarbitone 33 mg kg–1 i.p. and acepromazine 0.6 mg kg–1 i.p., the trachea was intubated, and the lungs ventilated with nitrous oxide in oxygen. Mean arterial pressure (MAP), heart rate (HR), twitch response and ICP were recorded continuously. After the effect of vecuronium had been ascertained under the condition of normal ICP, and after full recovery of twitch response, pH-adjusted Ringer's lactate solution was infused to the cisterna magna until an ICP baseline of 26±2 mm Hg was established, and had stabilized. Vecuronium was administered again to determine its effect under the condition of increased ICP. Complete ablation of twitch response was obtained in 68±15 s with vecuronium 80 µg kg–1, and there was no significant change in ICP, MAP, HR or cerebral perfusion pressure (CPP) under either ICP condition.


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