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British Journal of Anaesthesia, 1986, Vol. 58, No. 4 415-421
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

RESTORATION OF BAROREFLEX CONTROL OF HEART RATE DURING RECOVERY FROM ANAESTHESIA

J. A. CARTER, M.B., B.S., F.F.A.R.C.S., T. N. S. CLARKE, M.A., B.M., B.CH., D.PHIL, F.F.A.R.C.S., C. PRYS-ROBERTS, M.A., D.M., PH.D., F.F.A.R.C.S. and K. R. SPELINA, M.D.(PRAGUE), L.R.C.P., M.R.C.S., F.F.A.R.C.S.

Sir Humphry Davy Department of Anaesthesia, University of Bristol Bristol Royal Infirmary, Bristol BS2 8HW

The effects on baroreflex control of heart rate of halothane or methohexitone used to supplement 67% nitrous oxide in oxygen have been studied in 21 patients. Stable anaesthesia with either agent caused depression of baroreflex sensitivity by more than 50%. The set point of the reflex was also changed by both agents, but in opposite directions. Halothane administration resulted in slower heart rates at lower arterial pressures, whereas the infusion of methohexitone caused faster heart rates at lower arterial pressure. During recovery from anaesthesia, there was a rapid return of baroreflex sensitivity to normal and this was achieved before the patients regained consciousness, with no difference between the two groups. The reflex was reset rapidly and repeatedly during the recovery phase.


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