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British Journal of Anaesthesia, 1986, Vol. 58, No. 4 371-377
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

I. V. SEDATION FOR CONSERVATIVE DENTISTRY

A Comparison of Midazolam and Diazepam

I. BARKER, M.B., CH.B., F.F.A.R.C.S., D. G. M. BUTCHART, L.D.S., M.D.SC., J. GIBSON, R.G.N., S.C.M., J. I. M. LAWSON, M.B., CH.B., F.F.A.R.C.S. and N. MACKENZIE, M.B., CH.B., F.F.A.R.C.S.

Department of Anaesthesia, Ninewells Teaching Hospital Dundee DD2 IUD
Department of Conservative Dentistry, Dundee Dental Hospital 2 Park Place, Dundee DD1 4HR

Midazolam and the emulsion formulation of diazepam were compared in a cross-over study in 50 patients undergoing out-patient conservative dentistry, with particular regard to sedation and the quality of recovery. Both agents proved effective, but sedation was achieved more rapidly with midazolam (P = 0.001) and was more effective (P < 0.02). Significantly greater antero-grade amnesia for the dental procedure (P < 0.001) and a more rapid return to normal activities (P < 0.02) were found with midazolam. Psychometric testing, however, failed to show any objective differences between the treatments. A mean dose of midazolam 0.14 mg kg–1 was required to achieve sedation equating to 0.29 mg kg–1 of diazepam, although there was considerable variation between individual patients.

*Present address: Department of Anaesthetics, Royal Hallamshire Hospital, Sheffield S10 2RX.


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