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British Journal of Anaesthesia, 1986, Vol. 58, No. 10 1109-1115
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

INFUSION OF MIDAZOLAM IN PAEDIATRIC PATIENTS AFTER CARDIAC SURGERY

A. R. LLOYD-THOMAS, M.B., F.F.A.R.C.S.*, and P. D. BOOKER, M.B., F.F.A.R.C.S

The Royal Liverpool Children's Hospital Myrtle Street, Liverpool L7 7DG.

Correspondence to A.R.L-T.

Midazolam was given, by infusion, for the sedation of 10 children receiving intensive care after cardiac surgery. Plasma concentrations greater than 250 ng ml–1 were required for adequate sedation. Midazolam did not cumulate in eight of the 10 children, and these patients excreated the drug in a fashion similar to that by adults. However, midazolam did accumulate in two children, one with profound hepatic disturbance. In one of these patients recovery was slow following cessation of the infusion.

*Present address: The Department of Anaesthesia, Saint Bartholomew's Hospital, West Smithfield, London EC1A 7BE.


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