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British Journal of Anaesthesia, 1986, Vol. 58, No. 10 1100-1103
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

INFUSION OF VECURONIUM CONTROLLED BY A CLOSED-LOOP SYSTEM

J. W. DE VRIES, M.D., L.H.D.J. BOOIJ, M.D., PH.D., L. H. D. J. BOOIJ, PH.D and H. H. ROS, PH.D.

Department of Anesthesiology, Free University Amsterdam, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
Department of Medical Physics Free University Amsterdam, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.

Closed-loop control of neuromuscular blockade, using a semi-continuous infusion of vecuronium, is described. In 28 patients, the average neuromuscular transmission was between 13 and 17% of control. Requirements for vecuronium averaged 1.1 µg kg–1 min–1 (.8–1.5 fig kg–1 min–1). being in the same range as for repeated bolus injections. No side effects were observed. After the infusion was stopped recovery was rapid. Only three patients required induced reversal of blockade.


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