Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by YATE, P. M.
Right arrow Articles by MORTON, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by YATE, P. M.
Right arrow Articles by MORTON, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1986, Vol. 58, No. 10 1091-1099
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

COMPARISON OF INFUSIONS OF ALFENTANIL OR PETHIDINE FOR SEDATION OF VENTILATED PATIENTS ON THE ITU

P. M. YATE, M.B., B.S., F.F.A.R.C.S., S. M. SHORT, M.B., B.S., F.F.A.R.C.S, P. S. SEBEL, M.B., B.S., F.F.A.R.C.S.I, D. THOMAS, M.B., B.S. F.F.A.R.C.S and J. MORTON, MIC

Anaesthetics Unit, London Hospital Medical College Whitechapel, London E1 1BB.
Department of Anaesthetics, London Hospital Medical College Whitechapel, London E1 1BB.
Department of Chemical Pathology; London Hospital Medical College Whitechapel, London E1 1BB.

Sedation was studied in 30 patients requiring overnight ventilation in the intensive therapy unit (ITU). Patients received an infusion of either alfentanil or pethidine, supplemented with midazolam. The infusion rates were adjusted to provide optimal sedation as judged by a nurse, and measurements were made of quality of sedation, recovery and serum cortisol concentration. In addition, blood concentrations of alfentanil were measured to permit pharmacokinetic and pharmacodynamic analysis. Satisfactory sedation was achieved in both groups. The required infusion rate for alfentanil was between 0.4 and 0.5 µ kg–1 min–1. Recovery was good in both groups, apart from one patient in the alfentanil group, in whom recovery was greatly prolonged and alfentanil pharmacokinetics were abnormal. A difference was found in the metabolic response to surgery between the two groups, the response in the alfentanil group being significantly less marked.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Palliat MedHome page
F Goncalves, M. Bento, M Alvarenga, I Costa, and L Costa
Validation of a Consciousness Level Scale for Palliative Care
Palliative Medicine, September 1, 2008; 22(6): 724 - 729.
[Abstract] [PDF]

Home page
 JAMAHome page
M. E. Ostermann, S. P. Keenan, R. A. Seiferling, and W. J. Sibbald
Sedation in the Intensive Care Unit: A Systematic Review
JAMA, March 15, 2000; 283(11): 1451 - 1459.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.