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British Journal of Anaesthesia, 1986, Vol. 58, No. 10 1080-1084
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

DOSE REQUIREMENTS OF PROPOFOL BY INFUSION DURING NITROUS OXIDE ANAESTHESIA IN MAN

I: Patients Premedicated with Morphine Sulphate

K. R. SPELINA, M.D., F.F.A.R.C.S., D. P. COATES, M.B., B.S., C. R. MONK, M. B. CH.B., F.F.A.R.C.S, C. PRYS-ROBERTS, M.A., D.M., PH.D, I. NORLEY, M.SC., M.B., B.S., F.F.A.R.C.S. and M. J. TURTLE, M.B., B.S., F.F.A.R.C.S

Sir HUMPHY Davey Department of Anaesthesia, University of Bristol Bristol Royal Infirmary, Bristol BS2 8HW.

The study was performed to determine the ED50 and ED95 of a continuous infusion of the emulsion formulation of propofol during 67% nitrous oxide anaestheisa in 57 patients premed-icated with morphine sulphate 0.15 mg kg–1. Anaesthesia was induced with propofol 2 mg kg–1, and maintained before incision with a fixed-rate infusion of propofol to supplement nitrous oxide. The response to the first surgical incision, made at least 30 min after induction of anaesthesia, was observed. The ED50; was 53.5 µg kg–1 min–1 and the ED95 was 112.2 µg kg–1 min–1. At the time of the first surgical incision, the venous whole blood concentrations of propofol at the ED50 and ED95 infusion rates (EC50and EC95 were 1.66 µg ml–1 and 3.39 fig ml–1 respectively. The satisfactory maintenance of anaesthesia provided by nitrous oxide supplemented with propofol was associated with stability and rapid, uncomplicated recovery.


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