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British Journal of Anaesthesia, 1985, Vol. 57, No. 9 900-903
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

INHALED ANAESTHETICS HAVE NO EFFECT ON FERTILITY IN DROSOPHILA MELANOGASTER

Y. R. KUNDOMAL, PH.D* and J. M. BADEN, M.B.,B.S.,F.F.A.R.C.S.,M.R.C.P.(U.K.)

Department of Anesthesia, Stanford University School of Medicine (SUSM), Stanford California 94305and Anesthesiology Service, Veterans Administration Medical Center (VAMC), Palo Alto California 94304

* Address for correspondence: Anesthesiology Service, 112A, Veterans Administration Medical Center, 3801 Miranda Avenue, Palo Alto, Ca 94304, U.S.A.

The potential effects of enflurane, isoflurane, halothane, fluroxene and nitrous oxide on mortality and fertility in Drosophila melanogaster were examined. The LD50 value 1 day after exposure for 1 h was the same for males and females and was about 8% for enflurane, isoflurane and halothane, about 20% for fluroxene, and greater than 100% for nitrous oxide. Male and female fertility, however, were not affected by any of the anaesthetics, even at concentrations well above those used clinically.


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