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British Journal of Anaesthesia, 1985, Vol. 57, No. 9 866-871
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

AGE AND NATURE OF OPERATION INFLUENCE THE PHARMACOKINETICS OF MIDAZOLAM

K. W. HARPER, B.SC.,M.B.,F.F.A.R.C.S, P. S. COLLIER, B.PHARM.,PH.D.,M.P.S, J. W. DUNDEE, M.D.,PHD.,F.F.A.R.C.S., F.R.C.P., P. ELLIOTT, M.B., F.F.A.R.C.S, N. J. HALLIDAY, M.B., F.F.A.R.C.S and K. G. LOWRY, M.B., F.F.A.R.C.S

Departments of Anaesthetics, and Pharmacy, The Queen's University of Belfast Northern Ireland

1Correspondence to J. W. Dundee, Department of Anaesthetics, The Queen's University of Belfast, 97, Lisburn Road, Belfast, N. Ireland.

The pharmacokinetics of midazolam were studied in surgical patients given 0.3 mg kg-1 i.v. for either the induction of anaesthesia, or postoperative sedation following cardiopulmonary bypass. The short elimination half-life of midazolam (2.4 h in patients < 50 yr undergoing minor surgery) was significantly, although not markedly, prolonged with age (4.1 h in patients > 50 yr undergoing minor procedures) and by the nature of the operation (3.8 h after major operative procedures). These changes were the result of alterations in clearance and volume of distribution with age, and in volume of distribution with nature of operation.


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