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British Journal of Anaesthesia, 1985, Vol. 57, No. 8 811-813
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

case-report

PROBABLE HISTAMINE LIBERATION WITH ATRACURIUM

A Case Report

G. G. LAVERY, M.B., F.F.A.R.C.S, M. M. BOYLE, M.B.,B.CH.,B.A.0 and R. K. MIRAKHUR, M.D.,PH.D.,F.F.A,R.C.S

Department of Anaesthetics, Royal Victoria Hospital, Belfast and The Queen's University of Belfast Belfast

An histaminoid reaction after the administration of thiopentone and atracurium is described. Serial blood sampling showed no evidence of complement activation. Intradermal testing 6 weeks later yielded a positive result with atracurium (1 in 1000), but not with thiopentone. The clinical course of the reaction and the subsequent investigations suggest a direct pharmacological liberation of histamine.


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