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British Journal of Anaesthesia, 1985, Vol. 57, No. 8 782-788
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DISPOSITION OF VECURONIUM BROMIDE IN THE CAT

A. F. BENCINI, M.D., F.F.A.R.C.S1, A. H. J. SCAF, PH.D, S. AGOSTON, M.D., PH.D, M. C. HOUWERTJES, and U. W. KERSTEN,

Research Group of the Institutes of Anesthesiology and Clinical Pharmacology, State University of Gioningen The Netherlands.

1Correspondence to A.F.B., University Hospital, Institute for Anesthesiology, P.O. Box 30.001,9700 RB Groningen, The Netherlands.

The disposition of vecuronium bromide has been investigated in six normal cats (group I) and in six cats with ligated renal pedicles (group II). A combined fluorimetric and chromatographic technique was used to determine the concentrations of vecuronium and its metabolites in biological material. After i.v. injection of 0.6mg kg-1, vecuronium disappeared rapidly from the plasma of the normal cat. Concentrations decreased bi-exponentially with half-lives of 4.6 and 31 min, respectively. The steady state volume of distribution was 0.23 litre kg-1 and the clearance 11 ml min-1 kg-1. Seventy percent of an i.v. dose of vecuronium (or its metabolites) was recovered: 15 % in the urine, 40 % in the bile and 15 % in the liver. Only 3.8%of this consisted of the 3-hydroxy metabolite. There were no significant differences in pharmacokinetic data or in the amounts of vecuronium and its metabolites recovered in cats with ligated renal pedicles. The 15% of vecuronium normally excreted by the kidney was compensated for by increased hepatic and biliary concentration of vecuronium.


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