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British Journal of Anaesthesia, 1985, Vol. 57, No. 8 753-757
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

INFLUENCE OF TUBOCURARINE, PANCURONIUM AND ATRACURIUM ON BRONCHOMOTOR TONE

D. A. SIMPSON, M.B., F.F.A.R.C.S, D. J. WRIGHT, B.SC and J. E. HAMMOND, M.B., F.F.A.R.C.S*

Department of Anaesthetics, King's College Hospital Medical School, Denmark Hill London SE5 9RS
*Present address: Department of Anaesthetics, New East Surrey Hospital Redhill, Surrey

Specific airways conductance (s.Gaw) was measured using the forced airflow oscillation method to study the effects of tubocurarine, pancuronium and atracurium. Twenty-seven patients undergoing elective surgery were randomly allocated to receive one of the three drugs. A statisically significant mean change in s.Gaw from the baseline values for each drug was apparent only after administration of atracurium (at 6 min) (P < 005). Some individuals given atracurium or tubocurarine either showed large decreases in s. Gaw or cutaneous flushing, but only one patient showed both. Pharmacological release of histamine may be confined to individual tissues in these instances.


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