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British Journal of Anaesthesia, 1985, Vol. 57, No. 6 595-601
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

CONTINUOUS MONITORING OF BLOOD GLUCOSE CONCENTRATION DURING OPEN-HEART SURGERY

C. K. MCKNIGHT, M.B., CH.B., F.F.A.R.C.S.*,, M. ELLIOTT, M.D., F.R.C.S., D. T. DEREK, F.R.C.P., F.F.A.R.C.S., K. G. M. M. ALBERTI, F.R.C.P. and M. P. HOLDEN, M.B., F.R.C.S.

Department of Cardiothoracic Anaesthesia and Surgery, Freeman Hospital Newcastle upon Tyne NE7 7DN
Department of Clinical Biochemistry adn Metabolic Medicine, University of Newcastle upon Tyne, Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP

Continuous monitoring of blood glucose concentration was compared with frequent intermittent sampling in 12 non-diabetic adult patients undergoing open-heart surgery with cardiopulmonary by-pass using priming fluids free of glucose. Continuous monitoring revealed several changes which were not detected on intermittent sampling. Blood glucose concentration decreased by 2 mmol litre–1 ± 0.5 (SEM) (P < 0.01) immediately on the institution of CPB, and increased during the succeeding minutes. Rewarming from hypothermic by-pass was associated with a 3 (± 0.5)-mmol litre–1 increase in blood glucose concentration (P < 0.01). Commencement of infusions of sympathomimetic agents resulted in a similar increase.

* Present address: Newcastle General Hospital, Westgate Road, Newcastle upon Tyne.


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