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British Journal of Anaesthesia, 1985, Vol. 57, No. 6 578-580
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECTS OF THE RECTAL ADMINISTRATION OF DIAZEPAM

Diazepam Concentrations in Children Undergoing General Anaesthesia

H. SONANDER, M.D., PH.D., E. ARNOLD, B.SC. and K. NILSSON, M.D., PH.D.

Department of Anaesthesia and Intensive Care, Sahlgrenska Hispital Gothenburg, Sweden
Biological Department, Dumex Ltd Copenhagen, Denmark
Department of Pediatric Anaesthesia, Östra Hospital Gothenburg, Sweden

Correspondence to H.S.

Diazepam 1 mg/kg body weight was administered rectally to 14 children (11–22.5 kg) before minor surgery under general anaesthesia. Administration in solution (n = 7) resulted in a rapid increase in serum concentrations which were maintained for 8 h. Administration by suppository (n = 7) resulted in significantly lower serum concentrations at 10 and 20 min, but higher concentrations at 2 h. At other intervals the concentrations did not differ from those reached after administration of diazepam in rectal solution. These results favour the use of a solution when rectal diazepam is used for premedication in children.


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