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British Journal of Anaesthesia, 1985, Vol. 57, No. 6 554-561
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF ETOMIDATE ON THE AUDITORY EVOKED RESPONSE IN MAN

C. THORNTON, M.SC., C. P. H. HENEGHAN, B.A., B.M., B.CH., F.F.A.R.C.S., M. NAVARATNARAJAH, M.B., L.R.C.P., M.R.C.S., F.F.A.R.C.S., P. E. BATEMAN, B.SC. and J. G. JONES, M.D. F.R.C.P., F.F.A.R.C.S.

Division of Anaesthesia, Clinical Research Centre Watford Road, Harrow, Middlesex HA1 3UJ
Department of Anaesthetics, Northwick Park Hospital Watford Road, Harrow, Middlesex HA1 3UJ

Correspondence to C.T.

The effect of etomidate on the auditory evoked response was examined in a double-blind study carried out before the start of surgery. Fourteen patients were anaesthetized with 70% nitrous oxide and oxygen after induction with thiopentone. Ventilation was controlled. Seven of the patients received a continuous infusion of etomidate, increasing in five equal steps from 0.01 mg kg–1 min–1 to 0.05 mg kg–1 min–1 over a period of 50 min. The other seven received similarly an equivalent volume of saline. The patients given etomidate were easily distinguishable from those given saline, solely on the basis of changes in the early cortical peaks Pa and Nb. In the etomidate group the latencies of these peaks increased and their amplitudes decreased. These changes were linearly related to serum etomidate concentration. There was no effect of etomidate on the brainstem response.


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