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British Journal of Anaesthesia, 1985, Vol. 57, No. 5 512-514
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ENZYME INHIBITION BY STEROID ANAESTHETIC AGENTS DERIVED FROM PROGESTERONE

P. BANKS, M.A., D.PHIL. and C. B. PEACE

Department of Biochemistry, The University of Sheffield Sheffield S10 2TN

The anaesthetic potency of steroids related by metabolism to progesterone shows marked variation with small changes in structure. In addition, the same group of substances have varying abilities to inhibit bacterial luciferase competitively, although there is no correlation between anaesthetic and inhibition potency. The data do, however, show that closely related hydrophobic steroids are able to interfere with the catalytic activity of an enzyme selectively and, by inference, suggest that differences in anaesthetic potency could be a consequence of selective differences in ability to interact with a target protein.


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