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British Journal of Anaesthesia, 1985, Vol. 57, No. 5 509-511
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF THE EFFECTS OF ETOMIDATE, THIOPENTONE AND PROPOFOL ON CORTISOL SYNTHESIS

C. J. KENYON, PH.D., L. M. MCNEIL, B.SC. and R. FRASER, PH.D.

M.R.C. Blood Pressure Unit, Western Infirmary Glasgow, G11 6NT

Correspondence to C.J.K.

The inhibitory effects of etomidate, thiopentone and propofol on basal and ACTH-stimulated cortisol synthesis by isolated bovine adrenocortical cells have been examined. Concentrations required for 50% inhibition of ACTH-stimulated cortisol output were 1.1 x 10–4 mol litre–1 for propofol, 3 x 10–5 mol litre–1 for thiopentone and 4.6 x 10–1 mol litre–1 for etomidate. At concentrations likely to be achieved during anaesthesia, etomidate would block cortisol output by isolated cells, thiopentone might slightly reduce output and propofol would be unlikely to alter cortisol synthesis significantly.


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