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British Journal of Anaesthesia, 1985, Vol. 57, No. 5 505-508
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF PROPOFOL, THIOPENTONE AND ETOMIDATE ON ADRENAL STEROIDOGENESIS IN VITRO

A. LAMBERT, PH.D., R. MITCHELL and W. R. ROBERTSON, PH.D.

Department of Chemical Pathology, University of Manchester Clinical Sciences Building, Hope Hospital, Eccles Old Road, Salford, Greater Manchester M6 8HD

The i.v. anaesthetic agents propofol, thiopentone and etomidate inhibited ACTH-stimulated production of cortisol by guineapig dispersed adrenal cells in a dose-related manner. For two of the drugs, propofol and thiopentone, inhibition occurred over a similar concentration range: 2 x 10–5 – 5 x 10–4 mol litre–1. With etomidate, inhibition occurred over a much lower concentration range (5 x 10–8 – 5 x 10–6 mol litre–1). The concentrations of anaesthetic which induced 50% inhibition of cortisol secretion were propofol 1.7 x 10–4, thiopentone 1.6 x 10–4, and etomidate 1.0 x 10–7 mol litre–1.


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