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British Journal of Anaesthesia, 1985, Vol. 57, No. 5 493-496
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

CIRCULATORY RESPONSES TO THIOPENTONE AND TRACHEAL INTUBATION IN PATIENTS WITH CORONARY ARTERY DISEASE

Effects of Pretreatment with Labetalol

M. FISCHLER, M.D., C. DUBOIS, M.D., D. BRODATY, M.D., S. SCHLUMBERGER, M.D., J. C. MELCHIOR, M.D., D. GUILMET, M.D. and G. VOURC'H, F.F.A.R.C.S.

Department of Anaesthesia Centre Medico-Chirurgical Foch, 40 rue Worth, 92151 Suresnes, France
Department of Cardiovascular Surgery Centre Medico-Chirurgical Foch, 40 rue Worth, 92151 Suresnes, France

Correspondence to M.F.

The haemodynamic responses to induction and tracheal intubation have been studied in patients with coronary artery disease randomly assigned to a labetalol pretreatment group (n = 14) or to a placebo group (n = 16). Twelve hour before operation, treated patients received a bolus dose of labetalol 0.5 mg kg'1 followed by a constant infusion of 0.1 mg kg–1 h–1 i.v. Anaesthesia was induced with thiopentone and phenoperidine, and intubation performed following the administration of suxamethonium. At intubation, the changes in heart rate (P < 0.01), mean arterial pressure (P < 0.05) and rate-pressure product (P < 0.01) were significantly smaller in the labetalol group compared with the placebo group. Labetalol pretreatment appears satisfactory and may be useful in patients with coronary artery disease who have a normal left ventricular ejection fraction.


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