Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by KORINEK, A. M.
Right arrow Articles by VIARS, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KORINEK, A. M.
Right arrow Articles by VIARS, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1985, Vol. 57, No. 4 407-411
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF POSTOPERATIVE EXTRADURAL MORPHINE ON ADH SECRETION

A. M. KORINEK, M.D., M. LANGUILLE, M.D., F. BONNET, M.D., M. THIBONNIER, M.D., P. SASANO, M.D., A. LIENHART, M.D. and P. VIARS, M.D.

Département d'Anesthesie-Réanimation, Groupe Hospitalíer Pitié-Salpétrière, 83, boulevard de 1'Hôpital 75651 Paris Cedex, France
I.N.S.E.R.M. Unité 34 17, rue du Fer à Moulin, 75005 Paris, France

The effect of extradural morphine on antidiuretic hormone (ADH) secretion was assessed for the first 6 h after surgery in three groups of patients. Surgery was conducted under extradural bupivacaine: thereafter patients in group I (n = 6) received further injections of bupivacaine, patients in group II (n = 6) received an extradural injection of morphine and in patients in group III (n = 5) both bupivacaine and morphine, were administered extradurally. In group I, plasma ADH values remained unchanged throughout the study. In contrast, in the two groups of patients receiving extradural morphine a delayed and stepwise increase in plasma ADH concentration was documented. These results indicate that extradural morphine induces ADH secretion and suggest that this effect is the consequence of the migration of morphine to the brainstem.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.