Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (40)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HJORTSØ, N.-C.
Right arrow Articles by KEHLET, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HJORTSØ, N.-C.
Right arrow Articles by KEHLET, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1985, Vol. 57, No. 4 400-406
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECTS OF THE EXTRADURAL ADMINISTRATION OF LOCAL ANAESTHETIC AGENTS AND MORPHINE ON THE URINARY EXCRETION OF CORTISOL, CATECHOLAMINES AND NITROGEN FOLLOWING ABDOMINAL SURGERY

NIELS-CHRISTIAN HJORTSØ, M.D., NIELS JUEL CHRISTENSEN, M.D., TORBEN ANDERSEN, M.D. and HENRIK KEHLET, M.D.

Department of Surgery, Kommune-hospitalet Copenhagen, Denmark
Department of Anaesthesiology, Kommune-hospitalet Copenhagen, Denmark
Department of Internal Medicine and Endocrinology, Herlev Hospital Denmark

Address for correspondence: N.-C. Hjortsø, Department of Anaesthesiology, Kommunehospitalet, Copenhagen, DK-1399.

Twenty patients undergoing major abdominal surgery were allocated randomly to receive either general anaesthesia with low-dose fentanyl plus intermittent systemic morphine for postoperative pain or the same general anaesthetic plus extradural analgesia during and following surgery (local anaesthetics from before skin incision until 24 h after skin incision plus extradural morphine 4 mg every 12 h from 3 h to 72 h after skin incision). Postoperative pain scores were lower (P < 0.05) in the group receiving extradural analgesia, but this regimen failed to prevent the increase in the urinary excretion of cortisol, adrenaline, noradrenaline and nitrogen both on separate days and on cumulative measurements over 4 days. Pain scores did not correlate to urinary excretion of the various endocrine-metabolic indices either on separate days or over the cumulative 4-day period. It is concluded that the relief of pain per se has no major influence on the catabolic response to abdominal surgery.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. Yokoyama, Y. Itano, H. Katayama, H. Morimatsu, Y. Takeda, T. Takahashi, O. Nagano, and K. Morita
The Effects of Continuous Epidural Anesthesia and Analgesia on Stress Response and Immune Function in Patients Undergoing Radical Esophagectomy
Anesth. Analg., November 1, 2005; 101(5): 1521 - 1527.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
A. Rodgers, N. Walker, S Schug, A McKee, H Kehlet, A van Zundert, D Sage, M Futter, G Saville, T Clark, et al.
Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials
BMJ, December 16, 2000; 321(7275): 1493 - 1493.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Schricker, L. Wykes, and F. Carli
Epidural blockade improves substrate utilization after surgery
Am J Physiol Endocrinol Metab, September 1, 2000; 279(3): E646 - E653.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.