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British Journal of Anaesthesia, 1985, Vol. 57, No. 4 369-374
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

USE OF A CONTINUOUS INFUSION OF ALTHESIN IN NEUROANAESTHESIA

Changes in Cerebral Blook Flow, Cerebral Metabolism, the EEG and Plasma Alphaxalone Concentration

A. BENDTSEN, M.D., J. B. MADSEN, M.D., G. E. COLD, M.D., A. KRUSE, M.D., J. ASTRUP, M.D., J. ROSENØRN, M.D. and B. BLATT-LYON, M.D.

Department of Anaesthesiology Hvidovre Hospital, University Hospital, DK-2650 Hvidovre, Denmark
Department of Neurosurgery Hvidovre Hospital, University Hospital, DK-2650 Hvidovre, Denmark
Department of Clinical Neurophysiology Hvidovre Hospital, University Hospital, DK-2650 Hvidovre, Denmark

Correspondence to G.E.C., Department of Anaesthesiology 532, Hvidovre Hospital, Kettegard alle 30, 2650 Hvidovre, Denmark

Ten patients with small supratentorial tumours were studied during craniotomy. Cerebral blood flow (CBF) was measured in the contralateral hemisphere by a modification of the Kety and Schmidt technique using xenon-133 i.v. With an Althesin infusion rate of 0.2 ml kg–1 h–1, CBF was 24.4 ± 5.4 ml min–1/100 g and CMRo2 1.87 ± 0.44 ml min–1/100 g at Paco2, 4.1 ± 0.7 kPa (mean ± SD). During constant infusion rates of Althesin, steady values of CMRo2 were obtained, while an increase in infusion rate of 150% was associated with an increase in plasma alphaxalone concentration, a decrease in CMRo2 and a tendency of further EEG suppression. However, great inter- and intraindividual variations were present, and correlations between CMRo2, EEG activity and plasma alphaxalone concentration were weak.


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