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British Journal of Anaesthesia, 1985, Vol. 57, No. 4 361-368
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF ETOMIDATE AND ALTHESIN IN THE REDUCTION OF INCREASED INTRACRANIAL PRESSURE AFTER HEAD INJURY

N. M. DEARDEN, B.SC., M.B., CH.B., F.F.A.R.C.S.* and D. G. MCDOWALL, M.D., F.F.A.R.C.S.

Department of Anaesthesia, University of Leeds Leeds, Yorks

The increasing use of shorter-acting hypnotic agents to control intracranial pressure (ICP) following severe head injury has prompted a prospective double-blind controlled trial comparing the efficacy of etomidate and Althesin, given by i.v. infusion. Over the dose ranges used, the two drugs appeared equipotent in decreasing ICP whilst preserving cerebral perfusion pressure. However, in two patients (one in each group) ICP did not respond to hypnotic infusion, a feature noted in other studies to occur in a minority of patients. With the cessation of Althesin manufacture and the discussion about the use of etomidate infusions, it is timely to document the effectiveness of etomidate in decreasing ICP.

* Present address, for correspondence: Department of Surgical Neurology, Western General Hospital, Crewe Road, Edinburgh EH4 2XU.


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