Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by ÅKERMAN, S. B. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ÅKERMAN, S. B. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1985, Vol. 57, No. 3 329-332
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

A METHODOLOGICAL STUDY OF SPINAL (SUBARACHNOID) ANAESTHESIA IN THE RAT AND THE MOUSE

S. B. A. ÅKERMAN, PH.D.

Department of Pharmacology, Research and Development Laboratories, Astra Läkemedel AB S-151 85 Södertälje, Sweden

Rat and mouse were utilized as models to study the spinal (subarachnoid) anaesthetic effects of five commonly used local anaesthetic agents. Duration and frequency of motor and sensory blockade, and onset time were determined after injection of 5.0% lignocaine, 0.75% bupivacaine and 1.0% amethocaine to the same groups of rats with chronically implanted catheters in the lumbar subarachnoid space. Dose-response curves for lignocaine, mepivacaine, bupivacaine, amethocaine and cinchocaine were obtained after single intrathecal injection to the mouse. The relative potency and other characteristics of the compounds investigated were in agreement with results obtained in other species, including man. The techniques described may provide useful adjuncts to methods in larger animals for the evaluation of potential new spinal anaesthetic agents, and the study of various factors that may influence spinal anaesthesia.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
Y. Y. Poon, A. Y. W. Chang, S. F. Ko, and S. H. H. Chan
An Improved Procedure for Catheterization of the Thoracic Spinal Subarachnoid Space in the Rat
Anesth. Analg., July 1, 2005; 101(1): 155 - 160.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
I. Dobos, K. Toth, G. Kekesi, G. Joo, E. Csullog, W. Klimscha, G. Benedek, and G. Horvath
The Significance of Intrathecal Catheter Location in Rats
Anesth. Analg., February 1, 2003; 96(2): 487 - 492.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.