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British Journal of Anaesthesia, 1985, Vol. 57, No. 3 326-328
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

CLINICAL STUDY OF A LIGNOCAINE-PRILOCAINE CREAM TO RELIEVE THE PAIN OF VENEPUNCTURE

B. HALLEN, M.D., P. CARLSSON, M.D. and A. UPPFELDT, M.SCI, PHARM.

Department of Anaesthesia, Karolinska Hospital Box 60500, S-104 01 Stockholm, Sweden
Clinical Research Astra Läkemedel AB, S-151 85 Södertälje, Sweden

The efficacy of a topical anaesthetic formulation, EMLA 5% cream (Eutectic Mixture of Local Anaesthetics) in obtunding the pain produced by venepuncture, was determined in a double-blind randomized, cross-over study in 31 adult volunteers. Pain was registered on a 10-cm visual analogue scale. In each subject the mean pain score after treatment with EMLA was compared with that following placebo. Twenty-eight subjects had lower pain scores with EMLA, and in the remaining three subjects EMLA and placebo were equi-effective. Transient skin reactions (blanching, erythema and oedema) were observed with both formulations. These reactions were not found to be aggravated by repeated applications.


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